{"id":2,"date":"2023-11-15T04:15:37","date_gmt":"2023-11-15T04:15:37","guid":{"rendered":"https:\/\/fangbucks.com\/chenlab\/?page_id=2"},"modified":"2023-12-23T06:51:23","modified_gmt":"2023-12-23T06:51:23","slug":"publication","status":"publish","type":"page","link":"https:\/\/fangbucks.com\/chenlab\/publication\/","title":{"rendered":"\u9648\u653e \u5b9e\u9a8c\u5ba4@\u540c\u6d4e\u5927\u5b66"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"2\" class=\"elementor elementor-2\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d1aa92a e-flex e-con-boxed e-con e-parent\" data-id=\"d1aa92a\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6a80cc2a elementor-widget elementor-widget-text-editor\" data-id=\"6a80cc2a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h2><strong>Publication<\/strong><\/h2><h3><span style=\"text-decoration: underline;\"><strong>selected publications<\/strong><\/span><\/h3><p>*<b>:\u00a0<\/b>Equal contribution<br \/><strong>\u2020:\u00a0<\/strong>Corresponding author<\/p><ol><li><strong>Chen F*<\/strong>, Wang X*, &#8230;, Vrieze S, Liu DJ. Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing. <em><strong>Nature Genetics<\/strong><\/em>. 2023 Jan 26:1-0. (<a href=\"https:\/\/www.nature.com\/articles\/s41588-022-01282-x\">link<\/a>) (Media coverage: <a href=\"https:\/\/www.psu.edu\/news\/research\/story\/machine-learning-identifies-drugs-could-potentially-help-smokers-quit\/\"><em>Penn State News<\/em><\/a>, <a href=\"https:\/\/m.thepaper.cn\/newsDetail_forward_22020793\"><em>\u6f8e\u6e43\u65b0\u95fb<\/em><\/a>)<\/li><li>Saunders GRB*, Wang X*, <strong>Chen F*<\/strong>, \u2026, Liu DJ, Vrieze S. Genetic diversity fuels gene discovery for tobacco and alcohol use. <em><strong>Nature<\/strong><\/em>. 2022 Dec;612(7941):720-724. (<a href=\"https:\/\/www.nature.com\/articles\/s41586-022-05477-4\">link<\/a>) (Selected media coverage: <a href=\"https:\/\/www.psu.edu\/news\/research\/story\/many-genes-linked-alcohol-and-tobacco-use-are-shared-among-diverse-ancestries\/\"><em>Penn State News<\/em><\/a>, <a href=\"https:\/\/www.dailymail.co.uk\/sciencetech\/article-11513041\/Amount-alcohol-significantly-influenced-genes-study-finds.html\"><em>Daily Mail<\/em><\/a>, <a href=\"https:\/\/www.newscientist.com\/article\/2350516-thousands-of-genetic-variants-may-influence-smoking-and-alcohol-use\/\"><em>New Scientist<\/em><\/a>, <a href=\"https:\/\/www.genomeweb.com\/microarrays-multiplexing\/tobacco-alcohol-use-contributors-uncovered-multi-ancestry-gwas#.Y5EcHezMJPA\"><em>GenomeWeb<\/em><\/a>, <em><a href=\"https:\/\/www.natureasia.com\/ko-kr\/life-sci\/research\/14320\">Nature Asia<\/a>,\u00a0 <\/em><a href=\"https:\/\/www.nature.com\/articles\/d41586-022-04378-w?error=cookies_not_supported&amp;code=d480d9f4-057b-4910-bfbf-61d1f3bed133&amp;utm_medium=Social&amp;utm_campaign=nature&amp;utm_source=Twitter#Echobox=1670513246-1\"><em>Nature<\/em><em> News,<\/em><\/a>\u00a0<a href=\"https:\/\/www.nature.com\/articles\/d41586-022-03620-9\"><em>Companion research briefing at Nature<\/em><\/a>; <em><a href=\"https:\/\/www.witf.org\/2022\/12\/15\/groundbreaking-study-co-authored-by-penn-state-researcher-finds-new-genetic-clues-on-alcohol-and-tobacco-use\/\">WITF interview<\/a>, <a href=\"https:\/\/m.thepaper.cn\/newsDetail_forward_21239515\">\u6f8e\u6e43\u65b0\u95fb<\/a><\/em>)<\/li><li>Khunsriraksakul C, McGuire D, Sauteraud R, <strong>Chen F<\/strong>, Yang L, Wang L, &#8230;, Liu DJ. Integrating 3D genomic and epigenomic data to enhance target gene discovery and drug repurposing in transcriptome-wide association studies. <em><strong>Nature Communications<\/strong><\/em>. 2022 Jun 7;13(1):3258.\u00a0<span style=\"background-color: var(--wp--preset--color--raft-bg); color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-size: var(--wp--preset--font-size--normal); font-weight: var( --e-global-typography-text-font-weight ); text-align: var(--text-align);\"><span style=\"background-color: var(--wp--preset--color--raft-bg); color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-size: var(--wp--preset--font-size--normal); font-weight: var( --e-global-typography-text-font-weight ); text-align: var(--text-align);\">(<a href=\"https:\/\/www.nature.com\/articles\/s41467-022-30956-7\">link<\/a>) (Media coverage:\u00a0 <em><a href=\"https:\/\/www.psu.edu\/news\/research\/story\/new-machine-learning-technique-shows-how-drugs-can-be-repurposed\/\">Penn State News<\/a> and <a href=\"https:\/\/pennstatehealthnews.org\/2022\/06\/new-machine-learning-technique-shows-how-drugs-can-be-repurposed\/\">Penn State Health News<\/a><\/em>).<\/span><\/span><\/li><li><span style=\"background-color: var(--wp--preset--color--raft-bg); color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-size: var(--wp--preset--font-size--normal); font-weight: var( --e-global-typography-text-font-weight ); text-align: var(--text-align);\">\u00a0<\/span><span style=\"text-align: var(--text-align); background-color: var(--wp--preset--color--raft-bg);\">Sauteraud R, Stahl JM, James J, Englebright M, <strong>Chen F<\/strong>, Zhan X, Carrel L, Liu DJ. Inferring genes that escape X-Chromosome inactivation reveals important contribution of variable escape genes to sex-biased diseases. <em><strong>Genome research<\/strong><\/em>. 2021 Sep;31(9):1629-1637.\u00a0<\/span><span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); text-align: var(--text-align); background-color: var(--wp--preset--color--raft-bg); font-size: var(--wp--preset--font-size--normal);\"><span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); text-align: var(--text-align); background-color: var(--wp--preset--color--raft-bg); font-size: var(--wp--preset--font-size--normal);\">(<a href=\"https:\/\/genome.cshlp.org\/content\/early\/2021\/08\/23\/gr.275677.121\">link<\/a>)<\/span><\/span><\/li><li><span style=\"text-align: var(--text-align); background-color: var(--wp--preset--color--raft-bg);\"><span style=\"text-align: var(--text-align); background-color: var(--wp--preset--color--raft-bg);\">McGuire D, Jiang Y, Liu M, Weissenkampen JD, Eckert S, Yang L, <strong>Chen F<\/strong>, GSCAN, Berg A, Vrieze S, Jiang B, Li Q &amp; Liu DJ Model-based assessment of replicability for genome-wide association meta-analysis, <strong><em>Nature Communications<\/em> <\/strong>(<a href=\"https:\/\/www.nature.com\/articles\/s41467-021-21226-z\">link<\/a>) (media coverage: <em><a href=\"https:\/\/academictimes.com\/using-data-science-to-ease-the-necessary-burden-of-replicating-large-scale-studies\/\">AcademicTimes<\/a>, <a href=\"https:\/\/news.psu.edu\/story\/652654\/2021\/03\/30\/research\/new-statistical-method-eases-data-reproducibility-crisis\">Penn State News<\/a><\/em>)<\/span><\/span><\/li><li><span style=\"text-align: var(--text-align); background-color: var(--wp--preset--color--raft-bg);\">Cygan PH, Arnold-Croop SE, Weidman EA, <strong>Chen F<\/strong>, Liu DJ, Eyster ME, Carrel L. Investigation of discordant phenotype in mild Hemophilia A using whole exome sequencing. <em><strong>Thrombosis Research<\/strong><\/em>. 2020 Sep 1;193:36-9.\u00a0<\/span><span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); text-align: var(--text-align); background-color: var(--wp--preset--color--raft-bg); font-size: var(--wp--preset--font-size--normal);\"><span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); text-align: var(--text-align); background-color: var(--wp--preset--color--raft-bg); font-size: var(--wp--preset--font-size--normal);\">(<a href=\"https:\/\/www.thrombosisresearch.com\/article\/S0049-3848(20)30216-4\/fulltext\">link<\/a>)<\/span><\/span><\/li><li>Cygan PH, Arnold-Croop SE, Weidman EA, <strong>Chen F<\/strong>, Liu DJ, Eyster ME, Carrel L. Bleeding in Mild Hemophilia A Due to a Splice-Site F8 Mutation May be Fully Abrogated By Prothrombotic Gene Variants. <em><strong>Blood<\/strong><\/em>. 2019 Nov 13;134:1125. (<a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S000649711859042X\">link<\/a>)<\/li><li><span style=\"text-align: var(--text-align); background-color: var(--wp--preset--color--raft-bg);\">Liu M, Jiang Y, Wedow R, Li Y, Brazel DM, <strong>Chen F<\/strong>, Datta G, &#8230;, Abecasis G, Liu DJ, Vrieze S. Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use. <em><strong>Nature Genetics<\/strong><\/em>. 2019 Feb;51(2):237-244.\u00a0<\/span><span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); text-align: var(--text-align); background-color: var(--wp--preset--color--raft-bg); font-size: var(--wp--preset--font-size--normal);\">(<a href=\"https:\/\/www.nature.com\/articles\/s41588-018-0307-5\">link<\/a>)\u00a0<\/span><span style=\"text-align: var(--text-align); background-color: var(--wp--preset--color--raft-bg);\"><span style=\"text-align: var(--text-align); background-color: var(--wp--preset--color--raft-bg);\">(media coverage: <em><a href=\"https:\/\/www.genomeweb.com\/genetic-research\/hundreds-genetic-variants-implicated-tobacco-alcohol-use#.XEEn-s9KgkU\">GenomeWeb<\/a>, <a href=\"https:\/\/www.drugabuse.gov\/news-events\/news-releases\/2019\/01\/scientists-closer-to-finding-inherited-traits-in-addiction\">NIH\/NIDA<\/a>, <a href=\"https:\/\/www.thepaper.cn\/newsDetail_forward_3071707\">\u6f8e\u6e43\u65b0\u95fb<\/a>, <a href=\"https:\/\/pennstatehealthnews.org\/2019\/04\/scientists-discover-hundreds-more-genes-with-potential-link-to-smoking-and-drinking-addictions\/\">Penn State Health News<\/a>, <a href=\"http:\/\/Penn State News\" data-wplink-url-error=\"true\">Penn State News<\/a><\/em>)<\/span><\/span><\/li><li><span style=\"text-align: var(--text-align); background-color: var(--wp--preset--color--raft-bg);\">Cao L*, <strong>Chen F*<\/strong>, Yang X, Xu W, Xie J, Yu L. Phylogenetic analysis of CDK and cyclin proteins in premetazoan lineages. <em><strong>BMC evolutionary biology<\/strong><\/em>. 2014 Jan 17;14:10.\u00a0<\/span><span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); text-align: var(--text-align); background-color: var(--wp--preset--color--raft-bg); font-size: var(--wp--preset--font-size--normal);\"><span style=\"color: var( --e-global-color-text ); font-family: var( --e-global-typography-text-font-family ), Sans-serif; font-weight: var( --e-global-typography-text-font-weight ); text-align: var(--text-align); background-color: var(--wp--preset--color--raft-bg); font-size: var(--wp--preset--font-size--normal);\">(<a href=\"https:\/\/bmcecolevol.biomedcentral.com\/articles\/10.1186\/1471-2148-14-10\">link<\/a>)<\/span><\/span><\/li><li><span style=\"text-align: var(--text-align); background-color: var(--wp--preset--color--raft-bg);\"><strong>Chen F<\/strong>, Li R, Wang C, Cao L, Wang Y, Yu L. T\u2010LAK cell\u2010originated protein kinase is essential for the proliferation of hepatocellular carcinoma SMMC\u20107721 cells. <em><strong>Cell Biochemistry and Function<\/strong><\/em>. 2013 Dec;31(8):736-42. (<a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/abs\/10.1002\/cbf.2964\">link<\/a>)\u00a0<\/span><span style=\"text-align: var(--text-align); background-color: var(--wp--preset--color--raft-bg);\"><span style=\"color: rgba(0, 0, 0, 0); font-family: var( --e-global-typography-text-font-family ), Sans-serif;\"><span style=\"font-weight: var( --e-global-typography-text-font-weight );\">(link)<\/span><\/span><\/span><\/li><\/ol><h2>\u00a0<\/h2><h2>Selected Awards and Talks<\/h2><div><ul><li><strong>Bond and Bradley Travel Award (2021)<\/strong><br \/><em>Award at Penn State College of Medicine<\/em><\/li><li><strong>Charles J. Epstein Trainee Awards for Excellence in Human Genetics Research semifinalist (2020)<\/strong><br \/><em>Award at ASHG (American Society of Human Genetics)<\/em><\/li><li><strong>Trans-ethnic transcriptome-wide association study for smoking addiction in 1.3 million individuals yields insights into the biology of tobacco addiction and drug repurposing (2020)<\/strong><br \/><em>Platform Talk at ASHG (American Society of Human Genetics) 2020<\/em><\/li><li><b>The functional landscape and essential genes discovery in genetic etiology of tobacco use (2019)<br \/><\/b><em>Platform Talk at ASHG (American Society of Human Genetics) 2019<\/em><\/li><\/ul><\/div>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-37a2400 e-flex e-con-boxed e-con e-parent\" data-id=\"37a2400\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Publication selected publications *:\u00a0Equal contribution\u2020:\u00a0Corresponding author Chen F*, Wang X*, &#8230;, Vrieze S, Liu DJ. Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing. Nature Genetics. 2023 Jan 26:1-0. (link) (Media coverage: Penn State News, \u6f8e\u6e43\u65b0\u95fb) Saunders GRB*, Wang X*, Chen F*, \u2026, Liu DJ, Vrieze S. Genetic diversity fuels gene [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"_themeisle_gutenberg_block_has_review":false,"footnotes":""},"class_list":["post-2","page","type-page","status-publish","hentry"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u9648\u653e \u5b9e\u9a8c\u5ba4@\u540c\u6d4e\u5927\u5b66 - Chen Lab<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fangbucks.com\/chenlab\/publication\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"\u9648\u653e \u5b9e\u9a8c\u5ba4@\u540c\u6d4e\u5927\u5b66 - Chen Lab\" \/>\n<meta property=\"og:description\" content=\"Publication selected publications *:\u00a0Equal contribution\u2020:\u00a0Corresponding author Chen F*, Wang X*, &#8230;, Vrieze S, Liu DJ. Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing. Nature Genetics. 2023 Jan 26:1-0. (link) (Media coverage: Penn State News, \u6f8e\u6e43\u65b0\u95fb) Saunders GRB*, Wang X*, Chen F*, \u2026, Liu DJ, Vrieze S. 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Multi-ancestry transcriptome-wide association analyses yield insights into tobacco use biology and drug repurposing. Nature Genetics. 2023 Jan 26:1-0. (link) (Media coverage: Penn State News, \u6f8e\u6e43\u65b0\u95fb) Saunders GRB*, Wang X*, Chen F*, \u2026, Liu DJ, Vrieze S. 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