{"id":258,"date":"2023-12-24T06:29:01","date_gmt":"2023-12-24T06:29:01","guid":{"rendered":"https:\/\/fangbucks.com\/chenlab\/?page_id=258"},"modified":"2023-12-24T09:14:48","modified_gmt":"2023-12-24T09:14:48","slug":"research","status":"publish","type":"page","link":"https:\/\/fangbucks.com\/chenlab\/research\/","title":{"rendered":"\u7814\u7a76\u65b9\u5411"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"258\" class=\"elementor elementor-258\">\n\t\t\t\t<div class=\"elementor-element elementor-element-70f3b1e e-flex e-con-boxed e-con e-parent\" data-id=\"70f3b1e\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-dd33079 elementor-widget elementor-widget-text-editor\" data-id=\"dd33079\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3 style=\"font-size: var(--wp--preset--font-size--medium);\"><strong>\u4e00\u4e2a\u9886\u57df\uff0c\u4e24\u79cd\u8d8b\u52bf<\/strong><\/h3><p>\u00a0 \u00a0 \u00a0 \u00a0 \u5728\u7edf\u8ba1\u9057\u4f20\u5b66\u548c\u57fa\u56e0\u7ec4\u5b66\u9886\u57df\uff0c\u6211\u4eec\u89c2\u5bdf\u5230\u4e24\u79cd\u663e\u8457\u7684\u53d1\u5c55\u8d8b\u52bf\uff0c\u5b83\u4eec\u4ee3\u8868\u4e86\u8fd9\u4e2a\u5b66\u79d1\u7684<strong>\u6df1\u5ea6<\/strong>\u548c<strong>\u5e7f\u5ea6<\/strong>\u3002<\/p><p>\u00a0 \u00a0 \u00a0 \u00a0 \u9996\u5148\uff0c\u7814\u7a76\u7684\u4eba\u7fa4\u89c4\u6a21\u6b63\u5728\u663e\u8457\u6269\u5927\u3002\u7279\u522b\u662f\u5728\u5168\u57fa\u56e0\u7ec4\u5173\u8054\u7814\u7a76\uff08GWAS\uff09\u4e2d\uff0c\u6211\u4eec\u5df2\u7ecf\u80fd\u591f\u770b\u5230\u6db5\u76d6\u6570\u767e\u4e07\u4eba\u7684\u5e9e\u5927\u7814\u7a76\u6837\u672c\u3002\u8fd9\u79cd\u89c4\u6a21\u7684\u589e\u52a0\u4e0d\u4ec5\u63d0\u9ad8\u4e86\u6211\u4eec\u53d1\u73b0\u9057\u4f20\u53d8\u5f02\u4e0e\u7279\u5b9a\u75be\u75c5\u6216\u7279\u5f81\u76f8\u5173\u6027\u7684\u80fd\u529b\uff0c\u800c\u4e14\u4e5f\u52a0\u5f3a\u4e86\u7edf\u8ba1\u529b\uff0c\u4f7f\u6211\u4eec\u80fd\u591f\u8bc6\u522b\u66f4\u52a0\u7ec6\u5fae\u7684\u9057\u4f20\u5f71\u54cd\u3002<br \/>\u00a0 \u00a0 \u00a0 \u00a0 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\/>\u00a0 \u00a0 \u00a0 \u00a0 \u603b\u4f53\u800c\u8a00\uff0c\u8fd9\u4e24\u4e2a\u8d8b\u52bf\u2014\u2014\u5927\u89c4\u6a21\u4eba\u7fa4\u7814\u7a76\u548c\u4e2a\u4f53\u6c34\u5e73\u7684\u7cbe\u7ec6\u5206\u6790\u2014\u2014\u5171\u540c\u63a8\u52a8\u4e86\u7edf\u8ba1\u9057\u4f20\u5b66\u548c\u57fa\u56e0\u7ec4\u5b66\u9886\u57df\u7684\u5feb\u901f\u53d1\u5c55\uff0c\u4e3a\u6211\u4eec\u63d0\u4f9b\u4e86\u4ece\u5b8f\u89c2\u5230\u5fae\u89c2\u7684\u5168\u9762\u9057\u4f20\u89c6\u89d2\uff0c\u4f46\u540c\u65f6\u4e5f\u5bf9\u7814\u7a76\u4eba\u5458\u7684\u7efc\u5408\u80fd\u529b\u63d0\u51fa\u4e86\u8d8a\u6765\u8d8a\u9ad8\u7684\u8981\u6c42\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-e62f246 e-con-full e-flex e-con e-parent\" data-id=\"e62f246\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-512b7d5 elementor-widget elementor-widget-image\" data-id=\"512b7d5\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"1024\" height=\"815\" src=\"https:\/\/fangbucks.com\/chenlab\/wp-content\/uploads\/2023\/12\/Screenshot-2023-12-23-at-11.26.42-PM-1024x815.png\" class=\"attachment-large size-large wp-image-262\" alt=\"\" srcset=\"https:\/\/fangbucks.com\/chenlab\/wp-content\/uploads\/2023\/12\/Screenshot-2023-12-23-at-11.26.42-PM-1024x815.png 1024w, https:\/\/fangbucks.com\/chenlab\/wp-content\/uploads\/2023\/12\/Screenshot-2023-12-23-at-11.26.42-PM-300x239.png 300w, https:\/\/fangbucks.com\/chenlab\/wp-content\/uploads\/2023\/12\/Screenshot-2023-12-23-at-11.26.42-PM-768x611.png 768w, https:\/\/fangbucks.com\/chenlab\/wp-content\/uploads\/2023\/12\/Screenshot-2023-12-23-at-11.26.42-PM-1536x1223.png 1536w, https:\/\/fangbucks.com\/chenlab\/wp-content\/uploads\/2023\/12\/Screenshot-2023-12-23-at-11.26.42-PM-2048x1630.png 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a9bcb2a e-flex e-con-boxed e-con e-parent\" data-id=\"a9bcb2a\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f3a8a46 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"f3a8a46\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f4517dd e-flex e-con-boxed e-con e-parent\" data-id=\"f4517dd\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b09873b elementor-widget elementor-widget-text-editor\" data-id=\"b09873b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><strong>\u8bfe\u9898\u7ec4\u5df2\u6709\u6210\u679c\u548c\u57fa\u7840<\/strong><\/h3><p>\u00a0 \u00a0 \u00a0 \u00a0 \u4eba\u7c7b\u591a\u57fa\u56e0\u590d\u6742\u75be\u75c5(complex disease)\u662f\u73b0\u4ee3\u9057\u4f20\u5b66\u7684\u6838\u5fc3\u95ee\u9898\u4e4b\u4e00\u3002 \u9648\u653e\u6559\u6388\u5728\u524d\u671f\u7684\u4e3b\u8981\u5de5\u4f5c\u805a\u7126\u4e8e\u590d\u6742\u75be\u75c5\u9057\u4f20\u5206\u6790\u4e2d\u7684\u7edf\u8ba1\u9057\u4f20\u5b66\u65b0\u65b9\u6cd5\u5f00\u53d1\u548c\u5e94\u7528\u524d\u6cbf\u9886\u57df\u3002\u5176\u4e3b\u8981\u6210\u679c\u7531\u4e09\u90e8\u5206\u7ec4\u6210:<br \/>1\u3001\u9488\u5bf9\u591a\u79cd\u65cf\uff0c\u5927\u89c4\u6a21\u590d\u6742\u75be\u75c5\u6570\u636e\uff0c\u5f00\u53d1\u4e86\u9762\u5411\u5b9e\u9645\u5e94\u7528\u9700\u6c42\u7684\u5168\u65b0\u7b97\u6cd5\u548c\u8f6f\u4ef6\uff0c\u63d0\u9ad8\u4e86\u65b0\u7b97\u6cd5\u7684\u7edf\u8ba1\u6548\u529b\u548c\u8ba1\u7b97\u7cbe\u5ea6\uff0c\u540c\u65f6\u586b\u8865\u4e86\u73b0\u6709\u57fa\u56e0\u7ec4\u6570\u636e\u548c\u591a\u7ec4\u5b66(Multi-omics)\u6570\u636e\u53d1\u5c55\u901f\u5ea6\u4e0d\u5339\u914d\u7684\u9e3f\u6c9f;<br \/>2\u3001\u57fa\u4e8e\u5f00\u53d1\u7684\u65b0\u65b9\u6cd5\uff0c\u901a\u8fc7\u4e09\u767e\u4e07\u4eba\u8d85\u5927\u6837\u672c\u3001\u591a\u79cd\u65cf\u7fa4\u4f53\u9057\u4f20\u5206\u6790\uff0c\u5bf9\u70df\u9152\u6210\u763e\u7b49\u590d\u6742\u75be\u75c5\u7684\u9057\u4f20\u7ed3\u6784\u8fdb\u884c\u4e86\u6df1\u5ea6\u89e3\u6790\uff0c\u5e76\u9996\u6b21\u5bf9\u8be5\u590d\u6742\u75be\u75c5\u9057\u4f20\u53d8\u5f02\u4f4d\u70b9\u5728\u4e0d\u540c\u79cd\u65cf\u4eba\u7fa4\u4e4b\u95f4\u7684\u9057\u4f20\u6548\u5e94\u8fdb\u884c\u4e86\u8bc4\u4f30;<br \/>3\u3001\u6574\u5408\u591a\u7ec4\u5b66\u548c\u836f\u7269\u57fa\u56e0\u7ec4\u5b66\u6570\u636e\uff0c\u5229\u7528\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u8fdb\u884c\u836f\u7269\u91cd\u5b9a\u4f4d(drug repurposing)\u5206\u6790\uff0c\u4e3a\u590d\u6742\u75be\u75c5\u7684\u6cbb\u7597\u63d0\u4f9b\u4e86\u65b0\u601d\u8def\u3002<br \/>\u00a0 \u00a0 \u00a0 \u00a0 \u8fd9\u4e9b\u5f00\u62d3\u6027\u7814\u7a76\u6210\u679c\u4e0d\u4ec5\u5bf9\u4e8e\u6df1\u5ea6\u9610\u91ca\u590d\u6742\u75be\u75c5\u7684\u9057\u4f20\u673a\u5236\u6709\u91cd\u8981\u7684\u65b9\u6cd5\u521b\u65b0\u4ef7\u503c\uff0c\u8fd8\u63a8\u52a8\u57fa\u56e0\u7ec4\u5b66\u548c\u591a\u7ec4\u5b66\u5728\u65b0\u836f\u7814\u53d1\u5f53\u4e2d\u7684\u5e94\u7528\u8f6c\u5316\u524d\u666f\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2450c5b e-flex e-con-boxed e-con e-parent\" data-id=\"2450c5b\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-14f09d4 elementor-widget elementor-widget-image\" data-id=\"14f09d4\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"2048\" height=\"1152\" src=\"https:\/\/fangbucks.com\/chenlab\/wp-content\/uploads\/2023\/12\/Screenshot-2023-12-24-at-12.03.11-AM-2048x1152.png\" class=\"attachment-2048x2048 size-2048x2048 wp-image-270\" alt=\"\" srcset=\"https:\/\/fangbucks.com\/chenlab\/wp-content\/uploads\/2023\/12\/Screenshot-2023-12-24-at-12.03.11-AM-2048x1152.png 2048w, https:\/\/fangbucks.com\/chenlab\/wp-content\/uploads\/2023\/12\/Screenshot-2023-12-24-at-12.03.11-AM-300x169.png 300w, https:\/\/fangbucks.com\/chenlab\/wp-content\/uploads\/2023\/12\/Screenshot-2023-12-24-at-12.03.11-AM-1024x576.png 1024w, https:\/\/fangbucks.com\/chenlab\/wp-content\/uploads\/2023\/12\/Screenshot-2023-12-24-at-12.03.11-AM-768x432.png 768w, https:\/\/fangbucks.com\/chenlab\/wp-content\/uploads\/2023\/12\/Screenshot-2023-12-24-at-12.03.11-AM-1536x864.png 1536w\" sizes=\"(max-width: 2048px) 100vw, 2048px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-41c01ac e-flex e-con-boxed e-con e-parent\" data-id=\"41c01ac\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-27c3e98 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"27c3e98\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-793d4f1 e-flex e-con-boxed e-con e-parent\" data-id=\"793d4f1\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-adcb3e9 elementor-widget elementor-widget-text-editor\" data-id=\"adcb3e9\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h3><strong>\u73b0\u6709\/\u5728\u7814\u7814\u7a76\u65b9\u5411<\/strong><\/h3>\n<p>&nbsp; &nbsp; &nbsp; &nbsp; \u5b9e\u9a8c\u5ba4\u5c06\u7ee7\u7eed\u805a\u7126\u4e8e\u7edf\u8ba1\u9057\u4f20\u5b66\u65b0\u65b9\u6cd5\u5f00\u53d1\uff0c\u673a\u5668\u5b66\u4e60\u548c\u5927\u6570\u636e\u6280\u672f\u5728\u590d\u6742\u75be\u75c5\u9057\u4f20\u5206\u6790\u7684\u5e94\u7528\u7b49\u524d\u6cbf\u9886\u57df\uff1b\u7ed3\u5408\u5355\u7ec6\u80de\u6d4b\u5e8f\u6280\u672f\uff0c\u524d\u6cbf\u5927\u6570\u636e\u548c\u591a\u7ec4\u5b66\u6280\u672f\uff0c\u5f00\u53d1\u65b0\u7b97\u6cd5\u548c\u5de5\u5177\uff0c\u6df1\u5165\u5f00\u5c55\u590d\u6742\u75be\u75c5\u7684\u5173\u952e\u57fa\u56e0\u9274\u5b9a\u548c\u9057\u4f20\u7ed3\u6784\u89e3\u6790\uff0c\u63a8\u8fdb\u4e34\u5e8a\u8f6c\u5316\u5e94\u7528\u7814\u7a76\u3002<br>\u5177\u4f53\u4e09\u4e2a\u65b9\u5411\u7684\u7814\u7a76\u5185\u5bb9\u5305\u62ec\uff1a<br>1. \u7ee7\u7eed\u5f00\u5c55\u590d\u6742\u75be\u75c5\u65b9\u5411\u5927\u6570\u636e\u5206\u6790\u548c\u7edf\u8ba1\u9057\u4f20\u65b0\u7b97\u6cd5\u3001\u65b0\u5de5\u5177\u7684\u5f00\u53d1\uff0c\u4fdd\u6301\u524d\u6cbf\u9886\u57df\u56fd\u9645\u5408\u4f5c\uff1b<br>2. \u63a8\u8fdb\u65b0\u836f\u9776\u70b9\u9a8c\u8bc1\u548c\u836f\u7269\u91cd\u5b9a\u4f4d\u4e34\u5e8a\u8f6c\u5316\uff0c\u901a\u8fc7\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u5f00\u53d1\uff0c\u5e72\u6e7f\u7ed3\u5408\u9a8c\u8bc1\uff0c\u5b8c\u6210\u9776\u70b9\u53d1\u6398\u548c\u9274\u5b9a\u7684\u5e73\u53f0\u5efa\u8bbe\uff1b<br>3. \u6df1\u5165\u4e1c\u4e9a\u4eba\u7fa4\u590d\u6742\u75be\u75c5\uff08\u5982\u80ba\u7ea4\u7ef4\u5316\uff0c\u5fc3\u8840\u7ba1\u75be\u75c5\u7b49\uff09\u7684\u7814\u7a76\uff0c\u7b5b\u9009\u4e1c\u4e9a\u4eba\u7fa4\u4e2d\u76f8\u5173\u75be\u75c5\u7684\u7279\u5f02\u4f4d\u70b9\uff1b\u901a\u8fc7\u5355\u7ec6\u80de\u5206\u6790\u548c\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\uff0c\u6784\u5efa\u590d\u6742\u75be\u75c5\u5355\u7ec6\u80de\u56fe\u8c31\uff0c\u4f18\u5316\u5fc3\u8840\u7ba1\u75be\u75c5\u9884\u9632\u6a21\u578b\uff0c\u63a8\u52a8\u7cbe\u51c6\u533b\u5b66\u548c\u516c\u5171\u536b\u751f\u9884\u9632\u7814\u7a76\u7684\u8f6c\u5316\u5e94\u7528\u5f00\u53d1\u3002<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-535e8ce e-flex e-con-boxed e-con e-parent\" data-id=\"535e8ce\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-a22fc10 e-con-full e-flex e-con e-child\" data-id=\"a22fc10\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4fa8dbc elementor-widget elementor-widget-text-editor\" data-id=\"4fa8dbc\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4 class=\"wp-block-heading\" style=\"margin-block: 24px 0px; font-size: var(--wp--preset--font-size--large); color: #292e29; font-family: 'Source Serif Pro', serif;\" data-l-s=\"73285\">\u7edf\u8ba1\u9057\u4f20\u5b66\u4e0e\u57fa\u56e0\u7ec4\u5b66<\/h4><p>\u5927\u89c4\u6a21\u57fa\u56e0\u5173\u8054\u7814\u7a76(GWAS)\u662f\u590d\u6742\u6027\u72b6\u548c\u75be\u75c5\u7814\u7a76\u7684\u91cd\u8981\u9a71\u52a8\u529b\uff0c\u5b83\u53ef\u4ee5\u5e2e\u52a9\u63ed\u793a\u57fa\u56e0\u4e0e\u76f8\u5173\u6027\u72b6\u548c\u75be\u75c5\u7684\u5173\u7cfb\u3001\u6539\u5584\u75be\u75c5\u7684\u8bca\u65ad\u548c\u9884\u9632\u3001\u4e3a\u540e\u7eed\u57fa\u56e0\u529f\u80fd\u7814\u7a76\u63d0\u4f9b\u5173\u952e\u7ebf\u7d22\u3002\u800c\u968f\u7740\u6280\u672f\u548c\u65b9\u6cd5\u8fdb\u6b65\uff0c\u8f6c\u5316\u533b\u5b66\u5b9e\u9645\u5e94\u7528\u4e2d\u5bf9\u4e8e\u7cbe\u51c6\u5ea6\u548c\u9057\u4f20\u591a\u6837\u6027\u9700\u6c42\u7684\u63d0\u5347\uff0cGWAS\u5df2\u7ecf\u8fdb\u5165\u5230\u8d85\u5927\u89c4\u6a21\uff0c\u591a\u7956\u5148\u6837\u672c\u65f6\u4ee3\uff0c\u8fd9\u4e00\u53d8 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class=\"elementor-element elementor-element-9235b4c e-con-full e-flex e-con e-child\" data-id=\"9235b4c\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-abb4aa1 elementor-widget elementor-widget-image\" data-id=\"abb4aa1\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1536\" height=\"818\" src=\"https:\/\/fangbucks.com\/chenlab\/wp-content\/uploads\/2023\/12\/Screenshot-2023-12-24-at-12.40.18-AM-1536x818.png\" class=\"attachment-1536x1536 size-1536x1536 wp-image-280\" alt=\"\" srcset=\"https:\/\/fangbucks.com\/chenlab\/wp-content\/uploads\/2023\/12\/Screenshot-2023-12-24-at-12.40.18-AM-1536x818.png 1536w, https:\/\/fangbucks.com\/chenlab\/wp-content\/uploads\/2023\/12\/Screenshot-2023-12-24-at-12.40.18-AM-300x160.png 300w, https:\/\/fangbucks.com\/chenlab\/wp-content\/uploads\/2023\/12\/Screenshot-2023-12-24-at-12.40.18-AM-1024x545.png 1024w, https:\/\/fangbucks.com\/chenlab\/wp-content\/uploads\/2023\/12\/Screenshot-2023-12-24-at-12.40.18-AM-768x409.png 768w, https:\/\/fangbucks.com\/chenlab\/wp-content\/uploads\/2023\/12\/Screenshot-2023-12-24-at-12.40.18-AM-2048x1091.png 2048w\" sizes=\"(max-width: 1536px) 100vw, 1536px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0d3fc0c e-flex e-con-boxed e-con e-parent\" data-id=\"0d3fc0c\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-d85ba0b e-con-full e-flex e-con e-child\" data-id=\"d85ba0b\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7a961ec elementor-widget elementor-widget-text-editor\" data-id=\"7a961ec\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4 class=\"wp-block-heading\" data-l-s=\"59010\">\u4eba\u5de5\u667a\u80fd\u4e0e\u65b0\u836f\u5f00\u53d1<\/h4><p>\u5f00\u53d1\u548c\u8fd0\u7528\u5927\u6570\u636e\u65b9\u6cd5\u5bf9\u590d\u6742\u75be\u75c5\u8fdb\u884c\u9057\u4f20\u7ed3\u6784\u89e3\u6790\u548c\u751f\u7269\u5b66\u673a\u5236\u63a2\u7d22\u7684\u6700\u7ec8\u76ee\u7684\u662f\u8fdb\u884c\u6709\u6548\u7684\u4e34\u5e8a\u8f6c\u5316\u3002\u5728\u8fd9\u4e00\u65b9\u5411\uff0c\u5b9e\u9a8c\u5ba4\u4f1a\u5ef6\u7eed\u5728\u65b0\u836f\u91cd\u5b9a\u4f4d\u4e0a\u7684\u5de5\u4f5c\uff0c\u4f18\u5316\u57fa\u56e0\u7ec4\u5bcc\u96c6\u5de5\u5177\uff0c\u6574\u5408\u8fd1\u66f4\u591a\u7ec4\u5b66\u4fe1\u606f\uff0c\u5145\u5206\u5f00\u53d1\u548c\u5229\u7528\u76f8\u5e94\u7684\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\uff0c\u8fdb\u4e00\u6b65\u5b8c\u5584\u8ba1\u7b97\u751f\u7269\u5b66(in silico)\u836f\u7269\u91cd\u5b9a\u4f4d\u5e73\u53f0\u3002\u5b9e\u9a8c\u5ba4\u8fd8\u4f1a\u901a\u8fc7\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u5f00\u5c55\u9776\u70b9\u9a8c\u8bc1\u4f53\u7cfb\uff0c\u5bf9\u4e8e\u7b5b\u9009\u51fa\u7684\u836f\u7269\uff0c\u901a\u8fc7CRISPR \u57fa\u56e0\u6572\u9664\u5e93\u7b5b\u9009\uff0c\u4ece\u800c\u627e\u5230\u836f\u7269\u4f5c\u7528\u7684\u6f5c\u5728\u9776\u6807\u6216\u8005\u4fe1\u53f7\u901a\u8def\u3002\u5bf9\u4e8e\u6709\u6f5c\u529b\u7684\u4f5c\u7528\u9776\u70b9\uff0c\u6211\u4eec\u5c06\u4e0e\u540c\u6d4e\u5927\u5b66\u57fa\u7840\u533b\u5b66\u9662\u53ca\u4e1c\u65b9\u9644\u5c5e\u533b\u9662\u5fc3\u8840\u7ba1\u75c5\u5b66\u7814\u7a76\u4e2d\u5fc3\u7684\u57fa\u7840\u548c\u4e34\u5e8a\u7814\u7a76\u56e2\u961f\u5f00\u5c55\u6df1\u5165\u5408\u4f5c\uff0c\u5728iPSC\u591a\u80fd\u5e72\u7ec6\u80de\u548c\u5c0f\u9f20\u52a8\u7269\u6a21\u578b\u5c42\u9762\u8fdb\u4e00\u6b65\u6df1\u5165\u7814\u7a76\uff0c\u4ece\u800c\u63a8\u8fdb\u65b0\u836f\u9776\u70b9\u9a8c\u8bc1\u548c\u836f\u7269\u91cd\u5b9a\u4f4d\u4e34\u5e8a\u8f6c\u5316\uff0c\u901a\u8fc7\u5e72\u6e7f\u7ed3\u5408\uff0c\u5b8c\u6210\u9776\u70b9\u53d1\u6398\u548c\u9274\u5b9a\u7684 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https:\/\/fangbucks.com\/chenlab\/wp-content\/uploads\/2023\/12\/Screenshot-2023-12-24-at-12.52.10-AM-300x183.png 300w, https:\/\/fangbucks.com\/chenlab\/wp-content\/uploads\/2023\/12\/Screenshot-2023-12-24-at-12.52.10-AM-768x469.png 768w, https:\/\/fangbucks.com\/chenlab\/wp-content\/uploads\/2023\/12\/Screenshot-2023-12-24-at-12.52.10-AM-1536x937.png 1536w, https:\/\/fangbucks.com\/chenlab\/wp-content\/uploads\/2023\/12\/Screenshot-2023-12-24-at-12.52.10-AM-2048x1250.png 2048w\" sizes=\"(max-width: 1024px) 100vw, 1024px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2335ff4 e-flex e-con-boxed e-con e-parent\" data-id=\"2335ff4\" data-element_type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-ab41c59 e-con-full e-flex e-con e-child\" data-id=\"ab41c59\" data-element_type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fdb0aff elementor-widget elementor-widget-text-editor\" data-id=\"fdb0aff\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<h4 class=\"wp-block-heading\" data-l-s=\"33746\">\u91cd\u5927\u75be\u75c5\u5355\u7ec6\u80de\u56fe\u8c31<\/h4><p class=\"wp-block-heading\" 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repurposing)\u5206\u6790\uff0c\u4e3a\u590d\u6742\u75be\u75c5\u7684\u6cbb\u7597\u63d0\u4f9b\u4e86\u65b0\u601d\u8def\u3002\u00a0 \u00a0 \u00a0 \u00a0 \u8fd9\u4e9b\u5f00\u62d3\u6027\u7814\u7a76\u6210\u679c\u4e0d\u4ec5\u5bf9\u4e8e\u6df1\u5ea6\u9610\u91ca\u590d\u6742\u75be\u75c5\u7684\u9057\u4f20\u673a\u5236\u6709\u91cd\u8981\u7684\u65b9\u6cd5\u521b\u65b0\u4ef7\u503c\uff0c\u8fd8\u63a8\u52a8\u57fa\u56e0\u7ec4\u5b66\u548c\u591a\u7ec4\u5b66\u5728\u65b0\u836f\u7814\u53d1\u5f53\u4e2d\u7684\u5e94\u7528\u8f6c\u5316\u524d\u666f\u3002 \u73b0\u6709\/\u5728\u7814\u7814\u7a76\u65b9\u5411 &nbsp; &nbsp; &nbsp; &nbsp; 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\u00a0 \u00a0 \u00a0 \u603b\u4f53\u800c\u8a00\uff0c\u8fd9\u4e24\u4e2a\u8d8b\u52bf\u2014\u2014\u5927\u89c4\u6a21\u4eba\u7fa4\u7814\u7a76\u548c\u4e2a\u4f53\u6c34\u5e73\u7684\u7cbe\u7ec6\u5206\u6790\u2014\u2014\u5171\u540c\u63a8\u52a8\u4e86\u7edf\u8ba1\u9057\u4f20\u5b66\u548c\u57fa\u56e0\u7ec4\u5b66\u9886\u57df\u7684\u5feb\u901f\u53d1\u5c55\uff0c\u4e3a\u6211\u4eec\u63d0\u4f9b\u4e86\u4ece\u5b8f\u89c2\u5230\u5fae\u89c2\u7684\u5168\u9762\u9057\u4f20\u89c6\u89d2\uff0c\u4f46\u540c\u65f6\u4e5f\u5bf9\u7814\u7a76\u4eba\u5458\u7684\u7efc\u5408\u80fd\u529b\u63d0\u51fa\u4e86\u8d8a\u6765\u8d8a\u9ad8\u7684\u8981\u6c42\u3002 \u8bfe\u9898\u7ec4\u5df2\u6709\u6210\u679c\u548c\u57fa\u7840 \u00a0 \u00a0 \u00a0 \u00a0 \u4eba\u7c7b\u591a\u57fa\u56e0\u590d\u6742\u75be\u75c5(complex disease)\u662f\u73b0\u4ee3\u9057\u4f20\u5b66\u7684\u6838\u5fc3\u95ee\u9898\u4e4b\u4e00\u3002 \u9648\u653e\u6559\u6388\u5728\u524d\u671f\u7684\u4e3b\u8981\u5de5\u4f5c\u805a\u7126\u4e8e\u590d\u6742\u75be\u75c5\u9057\u4f20\u5206\u6790\u4e2d\u7684\u7edf\u8ba1\u9057\u4f20\u5b66\u65b0\u65b9\u6cd5\u5f00\u53d1\u548c\u5e94\u7528\u524d\u6cbf\u9886\u57df\u3002\u5176\u4e3b\u8981\u6210\u679c\u7531\u4e09\u90e8\u5206\u7ec4\u6210:1\u3001\u9488\u5bf9\u591a\u79cd\u65cf\uff0c\u5927\u89c4\u6a21\u590d\u6742\u75be\u75c5\u6570\u636e\uff0c\u5f00\u53d1\u4e86\u9762\u5411\u5b9e\u9645\u5e94\u7528\u9700\u6c42\u7684\u5168\u65b0\u7b97\u6cd5\u548c\u8f6f\u4ef6\uff0c\u63d0\u9ad8\u4e86\u65b0\u7b97\u6cd5\u7684\u7edf\u8ba1\u6548\u529b\u548c\u8ba1\u7b97\u7cbe\u5ea6\uff0c\u540c\u65f6\u586b\u8865\u4e86\u73b0\u6709\u57fa\u56e0\u7ec4\u6570\u636e\u548c\u591a\u7ec4\u5b66(Multi-omics)\u6570\u636e\u53d1\u5c55\u901f\u5ea6\u4e0d\u5339\u914d\u7684\u9e3f\u6c9f;2\u3001\u57fa\u4e8e\u5f00\u53d1\u7684\u65b0\u65b9\u6cd5\uff0c\u901a\u8fc7\u4e09\u767e\u4e07\u4eba\u8d85\u5927\u6837\u672c\u3001\u591a\u79cd\u65cf\u7fa4\u4f53\u9057\u4f20\u5206\u6790\uff0c\u5bf9\u70df\u9152\u6210\u763e\u7b49\u590d\u6742\u75be\u75c5\u7684\u9057\u4f20\u7ed3\u6784\u8fdb\u884c\u4e86\u6df1\u5ea6\u89e3\u6790\uff0c\u5e76\u9996\u6b21\u5bf9\u8be5\u590d\u6742\u75be\u75c5\u9057\u4f20\u53d8\u5f02\u4f4d\u70b9\u5728\u4e0d\u540c\u79cd\u65cf\u4eba\u7fa4\u4e4b\u95f4\u7684\u9057\u4f20\u6548\u5e94\u8fdb\u884c\u4e86\u8bc4\u4f30;3\u3001\u6574\u5408\u591a\u7ec4\u5b66\u548c\u836f\u7269\u57fa\u56e0\u7ec4\u5b66\u6570\u636e\uff0c\u5229\u7528\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\u8fdb\u884c\u836f\u7269\u91cd\u5b9a\u4f4d(drug repurposing)\u5206\u6790\uff0c\u4e3a\u590d\u6742\u75be\u75c5\u7684\u6cbb\u7597\u63d0\u4f9b\u4e86\u65b0\u601d\u8def\u3002\u00a0 \u00a0 \u00a0 \u00a0 \u8fd9\u4e9b\u5f00\u62d3\u6027\u7814\u7a76\u6210\u679c\u4e0d\u4ec5\u5bf9\u4e8e\u6df1\u5ea6\u9610\u91ca\u590d\u6742\u75be\u75c5\u7684\u9057\u4f20\u673a\u5236\u6709\u91cd\u8981\u7684\u65b9\u6cd5\u521b\u65b0\u4ef7\u503c\uff0c\u8fd8\u63a8\u52a8\u57fa\u56e0\u7ec4\u5b66\u548c\u591a\u7ec4\u5b66\u5728\u65b0\u836f\u7814\u53d1\u5f53\u4e2d\u7684\u5e94\u7528\u8f6c\u5316\u524d\u666f\u3002 \u73b0\u6709\/\u5728\u7814\u7814\u7a76\u65b9\u5411 &nbsp; &nbsp; &nbsp; &nbsp; 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\u5927\u89c4\u6a21\u57fa\u56e0\u5173\u8054\u7814\u7a76(GWAS)\u662f\u590d\u6742\u6027\u72b6\u548c\u75be\u75c5\u7814\u7a76\u7684\u91cd\u8981\u9a71\u52a8\u529b\uff0c\u5b83\u53ef\u4ee5\u5e2e\u52a9\u63ed\u793a\u57fa\u56e0\u4e0e\u76f8\u5173\u6027\u72b6\u548c\u75be\u75c5\u7684\u5173\u7cfb\u3001\u6539\u5584\u75be\u75c5\u7684\u8bca\u65ad\u548c\u9884\u9632\u3001\u4e3a\u540e\u7eed\u57fa\u56e0\u529f\u80fd\u7814\u7a76\u63d0\u4f9b\u5173\u952e\u7ebf\u7d22\u3002\u800c\u968f\u7740\u6280\u672f\u548c\u65b9\u6cd5\u8fdb\u6b65\uff0c\u8f6c\u5316\u533b\u5b66\u5b9e\u9645\u5e94\u7528\u4e2d\u5bf9\u4e8e\u7cbe\u51c6\u5ea6\u548c\u9057\u4f20\u591a\u6837\u6027\u9700\u6c42\u7684\u63d0\u5347\uff0cGWAS\u5df2\u7ecf\u8fdb\u5165\u5230\u8d85\u5927\u89c4\u6a21\uff0c\u591a\u7956\u5148\u6837\u672c\u65f6\u4ee3\uff0c\u8fd9\u4e00\u53d8 \u5316\u8981\u6c42\u63d0\u9ad8\u9057\u4f20\u7814\u7a76\u7ed3\u679c\u8d28\u91cf\u548c\u9057\u4f20\u591a\u6837\u6027\u7684\u540c\u65f6\uff0c\u4e5f\u5bf9\u4e8e\u7814\u7a76\u4eba\u5458\u7684\u80fd\u529b\u548c\u7ecf\u9a8c\u63d0\u51fa\u4e86\u66f4\u9ad8\u7684\u8981\u6c42\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u591a\u7ec4\u5b66\u6280\u672f\u548c\u5927\u578b\u516c\u5171\u6570\u636e\u5e93\u5feb\u901f\u53d1\u5c55\uff0c\u4e5f\u5e26\u6765\u4e86\u975e\u5e38\u591a\u7684\u9057\u4f20\u8d44\u6e90\u548c\u5e94\u7528\u9700\u6c42\uff0c\u8fd9\u5bf9\u4e8e\u6211\u4eec\u7684\u65b9\u6cd5\u7814\u7a76\u6709\u7740\u4e0d\u53ef\u66ff\u4ee3\u7684\u4f5c\u7528\u3002\u6211\u4eec\u901a\u8fc7\u5f00\u53d1\u65b0\u7684\u7edf\u8ba1\u9057\u4f20\u5b66\u65b9\u6cd5\uff0c\u5c06GWAS\u7ed3\u679c\u7edf\u8ba1\u6570\u636e\u548c\u529f\u80fd\u57fa\u56e0\u7ec4\u5b66\u591a\u7ec4\u5b66\uff08Multi-omics\uff09\u76f8\u7ed3\u5408\uff0c\u8fdb\u4e00\u6b65\u7814\u7a76\u751f\u7269\u4f53\u7684\u9057\u4f20\u53d8\u5f02\u3001\u57fa\u56e0\u8868\u8fbe\u8c03\u63a7\u4ee5\u53ca\u75be\u75c5\u53d1\u751f\u53d1\u5c55\u673a\u5236\u3002 \u4eba\u5de5\u667a\u80fd\u4e0e\u65b0\u836f\u5f00\u53d1 \u5f00\u53d1\u548c\u8fd0\u7528\u5927\u6570\u636e\u65b9\u6cd5\u5bf9\u590d\u6742\u75be\u75c5\u8fdb\u884c\u9057\u4f20\u7ed3\u6784\u89e3\u6790\u548c\u751f\u7269\u5b66\u673a\u5236\u63a2\u7d22\u7684\u6700\u7ec8\u76ee\u7684\u662f\u8fdb\u884c\u6709\u6548\u7684\u4e34\u5e8a\u8f6c\u5316\u3002\u5728\u8fd9\u4e00\u65b9\u5411\uff0c\u5b9e\u9a8c\u5ba4\u4f1a\u5ef6\u7eed\u5728\u65b0\u836f\u91cd\u5b9a\u4f4d\u4e0a\u7684\u5de5\u4f5c\uff0c\u4f18\u5316\u57fa\u56e0\u7ec4\u5bcc\u96c6\u5de5\u5177\uff0c\u6574\u5408\u8fd1\u66f4\u591a\u7ec4\u5b66\u4fe1\u606f\uff0c\u5145\u5206\u5f00\u53d1\u548c\u5229\u7528\u76f8\u5e94\u7684\u673a\u5668\u5b66\u4e60\u65b9\u6cd5\uff0c\u8fdb\u4e00\u6b65\u5b8c\u5584\u8ba1\u7b97\u751f\u7269\u5b66(in silico)\u836f\u7269\u91cd\u5b9a\u4f4d\u5e73\u53f0\u3002\u5b9e\u9a8c\u5ba4\u8fd8\u4f1a\u901a\u8fc7\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u5f00\u5c55\u9776\u70b9\u9a8c\u8bc1\u4f53\u7cfb\uff0c\u5bf9\u4e8e\u7b5b\u9009\u51fa\u7684\u836f\u7269\uff0c\u901a\u8fc7CRISPR 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silico)\u836f\u7269\u91cd\u5b9a\u4f4d\u5e73\u53f0\u3002\u5b9e\u9a8c\u5ba4\u8fd8\u4f1a\u901a\u8fc7\u57fa\u56e0\u7f16\u8f91\u6280\u672f\u5f00\u5c55\u9776\u70b9\u9a8c\u8bc1\u4f53\u7cfb\uff0c\u5bf9\u4e8e\u7b5b\u9009\u51fa\u7684\u836f\u7269\uff0c\u901a\u8fc7CRISPR 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